Dexpanthenol 81-13-0 Direct Manufacturer

Good producer 81-13-0 superior manufacturer Dexpanthenol

Description

Brand:乐动体育最新版本
Product Name:Dexpanthenol
Synonyms:4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-(theta)-butanamid;4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-d-(+)-butyramid;Alcopan-250;BepantheChemicalbookn;Bepanthene;Bepantol;Butanamide,2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-;Butanamide,2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-,(R)-
CAS No.:81-13-0
MF:C9H19NO4
MW:205.25
Packaging：25kg/Plastic drum,or according to the requirements of the customers

What is the use ofDexpanthenol

1. Used for hair care, skin moisturizer, and help skin wound healing, fight inflammation, and help repair after sun.
2.作为营养增补剂,D-panthenol widely used in the pharmaceutical, food, and cosmetic industries. Specific preparations include oral liquid, eye drops, multi-vitamin injections, shampoo, mousse, moisturizer, etc.
3.Pharmaceuticalintermediates.
4. It is the precursor ofvitaminB5.
5. Dexpanthenol (D-panthenol) is the equivalent of D-pantothenic acid, a precursor of coenzyme A, and an importantvitamindrug. It can be converted into pantothenic acid and then synthesized into coenzyme A when entering the human body, promoting human protein and fat , Carbohydrate metabolism, protect the mucous membrane and luster of the skin surface,乐动体育最新版本prevent the occurrence of diseases.

DexpanthenolSpecification

Items	Specification
Melting point	64～69℃
Boiling point	118-120 °C (2.7 mmHg)
Density	1.20 g/mL at 20 °C (lit.)
Refractive index	1.495-1.502
Flash point	118-120°C/0.02m
Storage conditions	−20°C
Form	Viscous Liquid or Semi Solid
Colour	Clear colorless to slightly yellow
水solubility	soluble
Sensitivity	Hygroscopic
Merck	142,947
BRN	1724947
Database	81-13-0(CAS DataBase Reference)
NIST化学物质信息	Dexpanthenol(81-13-0)
EPA chemical substance information	(+)-Panthenol (81-13-0)
Acidity coefficient (pKa)	13.03±0.20(Predicted)
PH	pH (100g/l,25℃) : 8.5～10.5
InChIKey	SNPLKNRPJHDVJA-ZETCQYMHSA-N
Alpha	30.5 º (c=5, H2O on anh. sub)
Optical activity	[α]20/D +30±1°, c = 5% in H2O
Appearance	Colorless or faintly yellow viscous hygroscopic liquid
Assay(on the anhydrous basis)	98.0~102.0%
水	≤1.0%
Specific optical rotation	+29.0°~+31.5°
Limit of aminopropanol	≤1.0%
Heavy metals	≤20ppm

Dexpanthenolusage and synthesis method

Dexpanthenol Description	D-panthenol is the precursor of coenzyme A and an important vitamin drug. It can be converted into pantothenic acid and then synthesized into coenzyme A when entering the human body. It promotes the metabolism of human protein, fat and carbohydrates, protects the mucous membrane and gloss on the skin surface, and prevents diseases. As a nutritional supplement, D-panthenol is widely used in the medicine, food, and cosmetic industries. Specific preparations such as oral liquid, eye drops, multivitamin injections, shampoo, mousse, moisturizer, etc.
Dexpanthenol Chemical Properties	It is a colorless to slightly yellow transparent viscous liquid, which may crystallize after long-term storage at low temperature. It has a slight special smell and is easy to absorb moisture. D-Panthenol is easily soluble inwater, methanol, ethanol, but insoluble in ether, chloroform, oil and fat. Relatively stable in the air and under light.
Dexpanthenol Scope of use	It is widely used in medicine, food and cosmetics industries. In the pharmaceutical industry, as a vitamin B drug, it participates in metabolism; In the food industry, it is used as a nutritional supplement and fortifier to promote the metabolism of human protein, fat and carbohydrates, maintain skin and mucous membranes, improve hair gloss, improve immunity, and prevent the occurrence of diseases; In the cosmetics industry: the skin care effect is expressed as a deeply penetrating moisturizer, which stimulates the growth of epithelial cells,pampromotes wound healing, and has an anti-inflammatory effect; the hair care effect is expressed as a long-lasting moisturizing function to prevent hair from splitting and damage , Increase the density of the hair and improve the gloss of the hair; the care of the nails is to improve the hydration of the nails and give the nails flexibility.
Dexpanthenol Identification test	Add 5ml sodium hydroxide test solution (TS-224) and copper sulfate test solution (TS-78) drops to 1Ml10% sample solution, and shake vigorously. It should appear dark blue. Add 1ml of 1mol/L hydrochloric acid to 1Ml1% sample aqueous solution, and heat it on the steam bath for about 30min. After cooling, add 100mg of hydroxylamine hydrochloride and mix well, then add 5ml of sodium hydroxide test solution (TS-224). After standing for 5 minutes, adjust the Ph value to 2.5-3.0 with 1mol/L hydrochloric acid, and add 1 drop of ferric chloride test solution (TS-101). It should appear reddish-purple.
Dexpanthenol Content analysis	Accurately weigh about 400 mg of the sample, put it in a 300 ml reflux flask with a standard mouth, add 50.0 mL of a glacial acetic acid solution of 0.1 mol/L perchloric acid, and reflux for 5 hours. After cooling, cover the condenser with metal foil to prevent water pollution, and rinse the condenser with glacial acetic acid. Add 5 drops of乐动体育最新版本crystal violet test solution (TS174), and then titrate with 0.1mol/L potassium hydrogen phthalate in glacial acetic acid solution to the blue-green end point. At the same time, carry out a blank test and make necessary corrections. Each mL of 0.1 mol/L perchloric acid is equivalent to 20.53 mg of panthenol (C9H19NO4).

How to make Dexpanthenol

D-pantolactone and 3-aminopropanol are mixed in methanol and condensed. The response is as follows:

cas 81-13-0 superior manufacturer

What are the safety issues ofDexpanthenol

Risk Statements	36/37/38-48-41-37/38-20/21/22
Hazard Codes	Xn
Safety instructions	23-24/25-45-36/37/39-26-22
RTECS number	ES4316000
F	‘3-10
TSCA	Yes
HS Code	29241990
Hazardous Substances Data	81-13-0(Hazardous Substances Data)
Toxicity	LD50 oral in mouse: 15gm/kg
WGK Germany	1

Upstream product information

Raw materials

3-amino-1-propanol

Product Storage

【Storage】

Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C). Store protected from moisture.

【Handling】

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.

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